[Protein-analysis] Re: protein shape change detection

Joe Doe None at mail.utexas.edu
Thu Sep 7 18:35:58 EST 2006

In article <mailman.879.1157471559.20007.proteins at net.bio.net>,
 "Carlo Zambonelli" <zambonel at gmail.com> wrote:

> Hi,
> I'm trying to find out what is the best technique to detect protein shape
> change (i.e. globular to non-globular) in solution. I believe the only
> options are analytical ultracentrifugation or SEC-MALLS. I don't have
> experience with either technique and I would appreciate any feedback,
> reference, etc.
> Thank you very much.
> CZ

It would be best to find a collaborator who is expert in the area or 
plan on spending a lot of time (the analysis is relatively simple but 
since it involves model fitting it needs very good data and obtaining a 
good data set will take a lot of time and effort).  The developer of the 
ULTRASCAN software package Bories Demeler at UT San Antonio has a couple 
of 2-3 day courses on the software package etc. that is offered once or 
twice a year.  The other developers (Peter Schuck) offer similar courses 
a few times a year though sometimes they are targeted at more advanced 
users.  If you cannot make it for one of these courses contacting them 
may put you in contact with a suitable euro labs.


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