correlation of IC50 to receptors/enzyme molecules

interpreneur_org at yahoo.com interpreneur_org at yahoo.com
Thu Feb 5 19:37:27 EST 2004

In a binding or kinetic assay, how does the IC50 of a compound change with respect to the number of receptors/enzyme molecules available? Is it linear (e.g: 10 times more protein leads to a 10 fold increase in the IC50)? Or not? And what is the mathematical equation explaining this?




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