Where in the cell are proteins ubiquitinylated?

Mitchell Isaacs misaacs at spam_me_not.student.usyd.edu.au
Wed Jun 20 16:23:08 EST 2001

"Stefan Kepinski" <ssk2 at york.ac.uk> wrote in message
news:3B30859E.ADBA45DD at york.ac.uk...
> Dear Protein net users,
> I have strayed in from the Arabidopsis net and I hope this is not a
> stupid question.  I can't seem to find any reference to the sub-cellular
> compartment within which the actual ubiquitin-modification takes place.
> I am particularly interested in SCF-mediated ubiquitination of nuclear
> proteins.
Hi Stefan,

As the name ubiquitin suggests, it is ubiquitous, or found everywhere.
Proteins tend to be ubiquitinated where they are usually located - either in
the cytosol or the nucleus (not sure about other compartments). There is
some evidence to suggest, however, that SOME nuclear proteins are exported
to the cytosol before ubiquitination (and there is also strong evidence than
many are ubiquitinated in the nucleus itself).

Don't have any references to hand at the moment, I'll post some later.


> Please point me in the direction of any relevant literature (or
> enlighten me yourself)
> Many Thanks
> Stefan Kepinski
> Plant Lab
> University of York
> ---

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