Is there such a thing? I've never heard of one, although I am,
admittedly, very new to the area. I've been able to stimulate the MAP
kinase pathway in a cell line by treating with insulin (1 uM). However,
I'd feel more comfortable with the conclusion that there are functional
insulin receptors present if I could block the signaling with an
antagonist.
Only I've never heard of one. Is there an antagonist for insulin receptors?
I'd be grateful for any information/insights.
(please reply to hines at pharm.med.upenn.edu)
John
