Does protein interation expose phosphorylation sites

Dominic-Luc Webb molmed domweb at mbox.ki.se
Tue Jun 5 20:27:04 EST 2001

I am hoping someone could point me to reliable information,
perhaps suitable references. I am confronted with a
crystal structure that shows that a phosphorylation site
I am interested in is masked from its kinase. I have reason
to believe that this site is made accessible to the kinase
when the kinase forms a complex with this protein.

Can someone please tell me if there are any known examples
of demonstrated discrepancies between experimental
phosphorylation studies and crystallography or some other
suitable example where a phosphorylation site is masked
from the kinase until the kinase reaches its target?

Any ideas and/or references would be greatly appreciated.


dominic at enk.ks.se

North 59 37' 30"
East  17 48' 10"

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