[snip]
>> It is generally asumed that proteins usually do indeed fold to the
> global minimum of Gibb's free enthalpy, and this is experimentally
> well supported for many of them (though there may be exceptions - but
> I'm currently not aware of any).
I think the work by Agard on alpha-lytic protease suggests something
like this. Then there's the whole prion/amyloid discussion which is far
from being solved.
Kresten
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