Are the serines glycosylated at all in the virus? Reason I ask is that
serine can be O-glycosylated in proteins (my experience....with mucins),
which if extensive enough can mask antigenic regions of your protein,
hence preventing the antibody-epitope interaction.
Just a thought
Kev
--
Kevin Brady
Lab B54
Organic Chemistry Section
School of Chemistry
University of Nottingham
Nottingham
NG7 2RD
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Emails : Work - rcxkb at unix.ccc.nottingham.ac.uk
Home - kevbrady1 at supanet.com
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