I am studying GP5 (envelope protein) from PRRS virus. It was found by a
coleague that the presence of a Serine or Threonine residue can kill the
reactivity with a monoclonal antibody. This new serine becomes part of
a serine string that "grows" from 3 or 4 serine residues in a row to 4
or 5 respectively (different strains have 3 some have 4). My real
question is: is there any antigenic relevance on the presence of a
serine string. This string is at the amino end and the substitution
takes place on aa34 (including signal peptide).
Sol M. Cancel
Graduate Student
Iowa State University
