Protein NMR Postdoctoral Associate

Honggao Yan yanh at pilot.msu.edu
Thu Apr 20 21:05:31 EST 2000

A postdoctoral position is available to study the structures and 
dynamics of the enzymes in the shikimate and folate biosynthetic 
pathways. Since the shikimate and folate biosynthetic pathways are 
unique to microbial and plant worlds, the two pathways are ideal targets 
for development of antimicrobial agents and herbicides. The long-term 
goals of the projects are to elucidate the structure-function 
relationships of these proteins that account for their catalytic 
mechanisms and to design specific inhibitors that may become new 
antimicrobial agents. A variety of techniques is employed in these 
projects, including recombinant DNA, biochemical, and biophysical 
methods. The main structural technique is multidimensional NMR 
spectroscopy. These projects are of great biomedical significance, 
especially in light of rapidly increasing antibiotic resistance in 
recent years that has rendered the current antibiotics ineffective for 
treating many microbial infections and caused a worldwide health care 
Our laboratory is well equipped for protein NMR spectroscopy. 
Instrumentation includes three computer workstations (one from SGI and 
two from Sun) and 500 MHz and 600 MHz Varian NMR spectrometers. The 600 
MHz Varian Inova NMR spectrometer is equipped with four rf channels and 
tri-axis pulsed field gradients and is dedicated to biomolecular NMR 
The initial appointment for the position will be two years and is 
renewable upon mutual agreement. The applicants should have experience 
with multidimensional NMR spectroscopy. If interested, please send a CV 
along with telephone numbers and email addresses of three references to 
the address below. Email responses are encouraged. 

Honggao Yan, Ph.D.
Associate Professor
Department of Biochemistry
Michigan State University
East Lansing, MI 48824

Tel: (517) 353-8786
Fax: (517) 353-9334
Email: yanh at msu.edu
Web: http://www.bch.msu.edu/faculty/yan.htm


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