IUBio

Can proteinase inhibitors penetrate the cell membrane?

Nick Theodorakis nicholas_theodorakis at urmc.rochester.edu
Tue Nov 16 17:38:06 EST 1999


In article <383175A8.3865DDA3 at uni-tuebingen.de>, Byung-Hoon Kim
<byung-hoon.kim at uni-tuebingen.de> wrote:
> Hi, all
> Can proteinase inhibitors (Aprotinin, Leupeptin and Pepstatin)
> penetrate
> the cell membrane?

Have you thought about using small, non-peptide inhibitors like PMSF or
TPCK? I'm not sure if either of these will penetrate the cell membrane,
but they may be more likely to than peptide inhibitors.

Nick



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