Dear all,
As we know that the "leucine zipper" has a pattern as L-x(6)-L-x(6)-
L-x(6)-L, a novel protein I am working on has two regions similar to this
pattern, reading as: region 1, L-x(6)-I-x(6)-L-x(6)-I-x(6)-L-x(6)-I (some I
- L replacements), and region 2, I-x(6)-V-x(6)-L-x(6)-I-x(6)-M (I, V, M, L
replacements). I wonder if the leucine residue in the "leucine zipper" can
be replaced by I, V, and M and the functions (dimerization?) remain with
the replacement?
Cheers.
ZhongLin Chai, PhD
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Department of Pathology and Immunology
Monash University Medical School
Alfred Hospital
Commercial Rd, Prahran, VIC 3181, AUSTRALIA
Telephone: (61 3) 9903 0698 (lab)
(61 3) 9903 0696 (office)
Mobile: 0413 58 1940 or International: +61 413 58 1940
Fax: (61 3) 9903 0731
email: zhonglin.chai at med.monash.edu.au
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