developmental control genes

Antonin Tutter atutter at aim.salk.edu
Fri Aug 13 17:08:38 EST 1999

> Does anyone have a good general definition of developmental control
> genes ?

i don't know if an 'official' definition exists, but my own definition,
stemming from  my own work on a 'developmental control' gene, is that it is
a gene that regulates certain other downstream genes (usually in trans in
the form of a transcription factor)) to ensure they only express at
precisely defined times during the development of an organism, such as
during mesoderm induction, segment polarity, limb development, etc.  these
control genes usually get switched on as a result of a signalling pathway,
and in turn regulate other downstream genes that will determine a particular
fate for the cell in which they are being expressed.  examples are the
homeobox genes and the wnt genes.

hope this sheds some light...

Antonin Tutter
Salk Institute for Biological Studies
10010 N. Torrey Pines Rd.
La Jolla, CA  92037
email:  tutter at salk.edu
web:  http://www-biology.ucsd.edu/~atutter/

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