Postdoctoral positions, protein synthesis and degradation.

[Keith D. Wilkinson]

Postdoctoral positions to study the regulation of protein synthesis and
degradation.

One project involves studies on the structure and mechanism of the RNA
binding protein, FMRP.  This protein appears to regulate the half-life
or translational activity of a subset or mRNAs and is missing or
defective in Fragile X Mental Retardation [JBC 273, 15521 (1998) ]. The
second project concentrates on ubiquitin-dependent processes,
particularly protein degradation. Special emphasis is placed on the
deubiquitinat-ing enzymes involved in processing polyubiquitin gene
products and in down-regulating ubiquitin-dependent processes  [EMBOJ.
16, 4826 (1997) ].

Experimental approaches include synthesis and chacterization of
substrates and inhibitors, identification and purification of proteins
involved, structural biology, genetics, and developmental biology.

Applicants should have a recent Ph.D. degree in the biological sciences,
a broad back-ground in cellular, structural, and/or molecular biology, a
strong publication record dem-onstrating accomplishment, and should be
available before March 1, 1999.

Responses should include a CV including career goals, a brief
description of past research accomplishments, and the names of three
references.  Reply by mail, email or Fax to:

Keith D. Wilkinson, Ph.D.
Professor of Biochemistry
Emory University School of Medicine
4017 Rollins Research Building
1510 Clifton Road
Atlanta, GA  30322

Phone: (404) 727-5980
Fax: (404) 727-3452
Email: genekdw at emory.edu

http://www.biochem.emory.edu/wilkinson/

Emory University is an Equal Opportunity/Affirmative Action Employer.

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Keith D. Wilkinson, Ph.D.
Department of Biochemistry           voice (404) 727-5980
4017 Rollins Research Building        fax  (404) 727-3452
1510 Clifton Road                     home (770) 413-2620
Emory University
Atlanta, GA 30322        e-mail genekdw at bimcore.emory.edu
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 http://www.biochem.emory.edu/bmb/faculty/wilkinson.html
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