In article <6a5men$s3c$1 at news4.isdnet.net>,
"Christophe GUENIN" <christophe.guenin at hol.fr> wrote:
>I have a dimerisation of receptor-G protein ( 7TM-7TM and 7TM-6TM).
>Does anybody know the phenomenon ?
>Thanks to give me explanation and bibliographic references.
>Sophie
>Paris,France
>e mail : christophe.guenin at hol.fr>
If you mean dimerization of two receptors, there many research groups
(including our lab) that are studying this phenomenon.
It has been suspected for a long time that G protein coupled receptors may
form dimers. In the past few years, there have been several papers that deal
with this issue directly.
Here is a list of some publications (It is definitely not a comprehensive
list, but, it's a start):
Maggio et al., PNAS 90: 3103, 1993
Ng et al., Biochem. Biophys. Res. Comm. 227: 200, 1996
Hebert et al., J. Biol. Chem. 271: 16384, 1996
Fukushima et al., FEBS Lett. 409: 283, 1997
Cvejic and Devi, J. Biol. Chem., 272: 26959, 1997
Nimchinsky et al., J. Biol. Chem., 272: 29229, 1997
I hope this helps.
Sam Lee
samuel.lee at utoronto.ca
Department of Pharmacology
University of Toronto
Toronto, ON, Canada
M5S 1A8
