Protein folding and Mr estimates

Pete pkursula at cc.oulu.fi
Fri Jan 23 04:03:35 EST 1998

On 22 Jan 1998, Cormac Shaw wrote:

> Hi folks,
> Semi-hypothetically speaking, what's the likelihood of this?:
> Two similar enzymes with essentially the same polypeptide chain length 
> and amino acid composition but with different folding conformations. 
> Niether are glycosylated.
> BUT the two have apparent relative molecular masses 
> of 74,000 and 79,000 on SDS-PAGE after treatment with 
> mercaptoethanol.
> Is this probable/possible/crazy? Any pointers towards references of 
> such occurances and/or comments very welcome. Maybe I'm just tired.
Could they (or one of them) be phosphorylated? That may have an effect.

|)    |/
|etri |\ursula

"I am somehow less interested in the weight and
convolutions of Einstein's brain than in the near
certainty that people of equal talent have lived
and died in cotton fields and sweatshops."
-- Stephen Jay Gould 

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