Protein folding and Mr estimates

Cormac Shaw cshaw at ollamh.ucd.ie
Thu Jan 22 16:24:23 EST 1998

Hi folks,

Semi-hypothetically speaking, what's the likelihood of this?:

Two similar enzymes with essentially the same polypeptide chain length 
and amino acid composition but with different folding conformations. 
Niether are glycosylated.
BUT the two have apparent relative molecular masses 
of 74,000 and 79,000 on SDS-PAGE after treatment with 

Is this probable/possible/crazy? Any pointers towards references of 
such occurances and/or comments very welcome. Maybe I'm just tired.


Cormac Shaw, BSc,                 |
Dept. of Industrial Microbiology, |  mailto:Cormac.Shaw at ucd.ie
University College Dublin,        |   phone: +353 (1) 706 1307
Dublin 4, Ireland                 |     fax: +353 (1) 706 1183
"Under the most rigorously controlled conditions of pressure,
temperature, volume, humidity, nutrients and other variables,
the organism will do as it pleases."

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