John Kuszewski wrote:
>
> How well do xray or NMR structures actually model
> reality in vivo?
>> I've seen some old papers showing that some enzymes
> still work in the crystalline state, but there
> must be something else about this.
>> Can anyone point me toward some references?
Hi, John!
You may find this paper of interest--especially since it deals with
quaternary structure and allostery in crystals vs. solution.
D.I. Svergun et al., PROTEINS: Str., Fn., Genet. 27 (1997),pp. 110-117.
"Large Differences Are Observed Between the Crystal and Solution
Quaternary Structures of Allosteric Aspartate Transcarbamylase in
the R State"
Nancy
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Nancy Vogelaar
Department of Chemistry Phone: (609) 258-2927
Princeton University Fax: (609) 258-6746
Princeton, NJ 08544 email: gc at atp.princeton.edu
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