Has anyone ever seen description of an anabolic enzyme (polymerase,
acetylase, kinase, etc) converted into a catabolic enzyme with the
specificity that is the reverse of the original anabolic one? For
example, can RNA polymerase be converted to a ribonuclease by mutation of
the RNA polymerase gene, or can a kinase be converted to a phosphatase in
a similar manner? Is there any example of this occuring naturally?
Thus, have any DNA endonucleases been sequenced and found to be similar
in structure to DNA ligase, etc? Any references would be of help! Thanks.
John Weiland
