Hi
I am looking for some recent references that deal with the mechanism of
action of Uricase for a paper I am doing for an enzyme mechanisms course at
OSU. I have read through many articles describing the sequence homology for
the various plants and bacteria, and the closest I have come to a mechanistic
study is from a study by Ito M. where he described a single mutation and gave
the resulting Km values.
If possible I would like to find some studies dealing with substrate analogs,
stereochemical aspects, and overall mechanism of action for the enzyme. Many
of the references I have located are from the 1960s and I know there must be
some more recent work out there somewhere.
Thanks in advance.
Thomas L Selby
tselby at magnus.acs.ohio-state.edu
