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>Article: 3569 of bionet.molbio.proteins
>From: smb18 at mole.bio.cam.ac.uk (Simon Brocklehurst (Bioc))
>have said, the technique is often much quicker than X-ray or NMR.
>Although I'd grant you the fact that if you're doing a structure by
>molecular replacement, and your data diffracts to 1 A, then you could
>knock it out in a weekend ;-) But us poor NMR people are stuck working
'poor NMR people'? gee, I think they are the richest!! :-)
[couldnt help looking at my bank(ruptcy) account!] :-(
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>
Article: 3586 of bionet.molbio.proteins
>As any person knows, using X-ray information without the theoretical
>stereochemical information would result in a 'random' collection of
>points.
Stereochemical information was not the contribution from modellers and
instead, most of them obtained from small molecular and inorganic crystals
by crystallography. In any case Crystallography is a SuperSet encompassing
all the available knowledge; not just X-ray information.
>> May I take the opportunity to suggest a simple test to see if homology
>> .....
>This is a good test of a usefulness of a model, but it is certainly not
>the only one.
Obviously Gerard has been trying to suggest some SIMPLE test to a
relatively newcomer and never claimed it to be THE TEST. So, why
keep on harping about it?
>Your view is probably a little too restrained. For example, a molecular
>.....
>deal with them.
In today's world if someone asks for a program to generate a 3D
structure from a sequence, then he needs to be cautioned. It surprises
me to see that homology modellers possess a fragile psychology that
makes them take offence at the slightest remark that was not intended
for slighting.
>
>Let's not create a tug of war between crystallographers and modelers.
>After all, we modelers depend on crystallographers for raw data and could
>not do anything without them.
...er..I am getting scared of chemists, molecular biologists, computer
scientists and physicists entering the newsgroup now...they might start
taking away the credit from us crystallographers!! :-)
>
>Regards, Andrej
Barani
B146 Lilly Hall of Life Sciences
Purdue University
