Erik Forbes Y. Hom (ehom1 at cc.swarthmore.edu) wrote:
: Does anyone know the latest ideas on how lithium interacts with G-proteins?
: Is the Li+ binding inositol phosphate idea still upheld?
There is a recent review about this topic in one of the latest PNAS issues,
together with a paper on the structure of inositol monophosphatase which
is apparently the enzyme Lithium interacts with (Jay M. Baraban: Towards
a crystal-clear view of lithium's site of action. PNAS 91(13), 5738-5739.
Scott J. Pollack, John R. Atack, Michael R. Knowles, George McAllister,
C. Ian Ragan, Raymond Baker, Stephen R. Fletcher, Leslie L. Iversen,
Howard B. Broughton: Mechanism of inositol monophosphatase, the putative
target of lithium therapy. PNAS 91(13), 5766-5770.)
I don't think that Lithium interactis with G proteins.
--Cornelius.
--
/* Cornelius Krasel, Abt. Lohse, Genzentrum, D-82152 Martinsried, Germany */
/* email: krasel at alf.biochem.mpg.de fax: +49 89 8578 3795 */
/* "People are DNA's way of making more DNA." (Edward O. Wilson, 1975) */
