Pi-bonding between Phe's - any references/help?

Duncan Purvis duncan at sgidemo
Tue Jul 19 22:22:22 EST 1994

Dave Myburgh (DAVID at chempath.uct.ac.za) wrote:

: I am interested in finding out more about pi-bonding between the rings of
: phenylalanines.  I have been unable to find anything useful myself, and was 
: hoping some of you may have some references or information that would help
: me understand this interaction.  My interest is in Phe residues interacting
: with each other in adjacent helices in transmembrane proteins (mainly G-
: protein coupled receptors).

: If anyone knows of a reference, I would really appreciate it.

The best reference I have seen on this subject is Hunter, CA, Singh, J, and
thornton, JM, Journal of Molecular Biology 218(4): 837-846, 1991 Apr20.
The title is Pi-pi interactions: the geometry and energetics of
phenylalanine-phenylalanine interactions in proteins. It applies the model
developed by Chris Hunter and Jeremy Sanders for pi-pi interactions to
proteins of all kinds.

I hope that this helps.


Duncan Purvis,
School of Biochemistry, University of New South Wales.

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