Dave Myburgh (DAVID at chempath.uct.ac.za) wrote:
: I am interested in finding out more about pi-bonding between the rings of
: phenylalanines. I have been unable to find anything useful myself, and was
: hoping some of you may have some references or information that would help
: me understand this interaction. My interest is in Phe residues interacting
: with each other in adjacent helices in transmembrane proteins (mainly G-
: protein coupled receptors).
: If anyone knows of a reference, I would really appreciate it.
The best reference I have seen on this subject is Hunter, CA, Singh, J, and
thornton, JM, Journal of Molecular Biology 218(4): 837-846, 1991 Apr20.
The title is Pi-pi interactions: the geometry and energetics of
phenylalanine-phenylalanine interactions in proteins. It applies the model
developed by Chris Hunter and Jeremy Sanders for pi-pi interactions to
proteins of all kinds.
I hope that this helps.
Cheers,
Duncan Purvis,
School of Biochemistry, University of New South Wales.
