QUESTIONS: alpha-helix "signals" in proteins

Ram Samudrala ram at mbisgi.umd.edu
Thu Jul 14 11:08:54 EST 1994

Toshiya Endo (d43162a at nucc.cc.nagoya-u.ac.jp) wrote:

>The tendency of proteins to fold fast to native conformations may not be 
>sequence independent.  Nature may well have selected proteins that can 
>fold fast, since polypeptides that remain unfolded in the cells are degraded 
>by specificf proteases. 

This is not a flame, but I think this is stating the obvious.  I
really don't see what Karplus, et al., have done in their paper that
was new.

And finally, Karplus in the Nature paper proposes something like the
framework model, but in protein science a few months ago he pushes the
diffusion-collision model (which I do like a lot---I think it's at
least one mechanism by which proteins fold), both which I find are
contradictory to each other.


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