Josh Mittledorf asked about concepts that could be utilitzed to reduce the
complexity of the protein folding problem (the "Levinthal Paradox"), such
that new algorithms could be developed. A good place to start would be
Martin Karplus' and Eugene Shakhnovich's chapter "Protein Folding:
Theoretical Studies of Thermodynamics and Dynamics" in Tom Creighton's book
"Protein Folding" (W.H. Freeman, New York, 1992). It's well written and
really addresses your question quite well. I'd enjoy a discussion of the
various models used to simulate the protein folding process; this chapter
appears to be a good point of embarkation. Best regards, Shaun
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= Shaun D. Black, PhD | Internet: shaun%jason.decnet at relay.the.net =
= Dept. of Biochemistry | University of Texas Health Center, at Tyler =
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