Schafmeister et al. (Science 262:734 (1993)) recently published a
method for solubilizing membrane proteins by complexing them with
alpha helices with one flat hydrophobic side to interact with the
transmembrane protein.
Two weeks ago I posted a message to bionet.molbio.proteins asking for
comments on the procedure, and whether such a method was general
enough so that crystal structures of a large number of membrane
proteins would soon be available. What follows is a summary of the
responses I received. Thanks to everyone who took the time.
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[This is from one of the authors of the paper...]
