IUBio

Protein Motifs and Profiles Databases

Dan Jacobson danj at welchgate.welch.jhu.edu
Thu May 27 16:31:27 EST 1993


In article <3265 at emoryu1.cc.emory.edu> bcresas at emoryu1.cc.emory.edu writes:
>Are there other protein motif-type databases available to search besides Prosite?
>
>
>Scott A. Sammons

I'm including some information about the Blocks database at the end of
this article.

To find more information - point your gopher client at merlot.welch.jhu.edu 
- if using Unix or Vax client just type:

gopher merlot.welch.jhu.edu

Select the following:

-->  13. Search Databases at Hopkins (Vectors, Promoters, NRL-3D, EST, OMIM../

 --> 9.  Seqanalref - Sequence Analysis Bibliographic Reference Data Ban.. <?>

Now search for motif*

 +---Seqanalref - Sequence Analysis Bibliographic Reference Data Bank----+
 |                      _____________                                    |
 | Words to search for  | motif*     |                                   |
 |                      -------------                                    |
 |                                  [Cancel ^G] [Accept - Enter]         |
 |                                                                       |
 +-----------------------------------------------------------------------+


And you'll get 85 entries - a sample entry is as follows:


------------

ID   GRIM8801
RM   88252899
RA   Gribskov M., Homyak M., Edenfield J., Eisenberg D.;
RT   "Profile scanning for three-dimensional structural patterns in protein
RT   sequences.";
RL   Comput. Appl. Biosci. 4:61-66(1988).
KW   PROTEIN; MATRIX-PROFILE.

Profile analysis  measures the  similarity between  a target sequence and a
group of  aligned sequences  (the probe).  The probe  sequences are used to
produce a position-specific scoring table (the profile) that can be aligned
with any  sequence (the target) using standard dynamic programming methods.
We are  developing a  library of  profiles,  each  describing  a  different
structural motif. This allows any target sequence to be rapidly scanned for
the  presence   of  structural  motifs.  Levels  of  significance  for  the
comparison of  target sequences with the profile are determined in advance,
permitting an  objective decision  to be  made as  to whether  a protein is
likely to possess a structural motif.

-------------- 


You might ant to narrow your search down a little bit - so try


 +---Seqanalref - Sequence Analysis Bibliographic Reference Data Bank----+
 |                      ________________________                         |
 | Words to search for  | motif* and database   |                        |
 |                      ------------------------                         |
 |                                  [Cancel ^G] [Accept - Enter]         |
 |                                                                       |
 +-----------------------------------------------------------------------+


Will yield 21 entries and the following will fill in the gap and yield
13 entries.


 +---Seqanalref - Sequence Analysis Bibliographic Reference Data Bank----+
 |                      _____________________________                    |
 | Words to search for  | motif* and data and bank   |                   |
 |                      -----------------------------                    |
 |                                  [Cancel ^G] [Accept - Enter]         |
 |                                                                       |
 +-----------------------------------------------------------------------+

You might also try searching the Gentools Bibliographys:

 -->  14. Search the GenTools Bibliography <?>


If you've never heard of gopher don't worry it's free and on the net.
Write me a note if you'd like info on hpw to get started.


Best of luck,

Dan Jacobson

danj at welchgate.welch.jhu.edu


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