I was wondering what everyone out there thinks about the recent article
by R.J.P.Williams (TIBS, April 1993) on enzymes as mechanical devices. I did
not think that it was an entirely new concept, especially for people who
appreciate protein structure, but I think it is a very elegant elaboration
of the conformational changes on an enzyme molecule during catalysis. I would
like to initiate a discussion on this if anyone is interested--to get a general
idea of what you people think. Thanks a lot.
Department of Biochemistry