affinity limits

Dan Szymanski Dan_Szymanski at QMS1.LIFE.UIUC.EDU
Sun Sep 20 21:05:00 EST 1992

                       Subject:                               Time:7:50 PM
  OFFICE MEMO          affinity limits                        Date:9/20/92
does anyone out there know anything about limits/predictions of affinity given
a number of starting conditions in the binding interaction, for example ionic
strength, electrostatic maps of ligand and binding site, h-bond configs.etc. 
Could one, for example, define an upper limit of affinity of a protein for DNA
given the above information, or what other info. is required?  Is it just a
matter of adding up the number of kcal each binding interaction is worth?

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