I am currently doing research on the selectivity of voltage gated ion
channels, which may include a ring of Asp residues and/or a ring of
Glu residues arranged in a 4-fold symmetry in the interior of an
8-stranded beta barrel. My question is does anyone know of any
work in the field that would allow me to predict how many of the
these four nearby residues would be charged? One would assume that
since they are in such close contact that not all of the group
would be charged. The effect of an ion binding at the site might also
effect the protonation of the residues.
Any help would be greatly appreciated.
Steve Bogusz
