I am a physicist investigating the binding and optical properties
of antibodies for possible sensor applications. My understanding
is that if an IgG antibody contains tryptophan in the binding
pocket, then the perturbation of the tryptophan luminescence
properties can be used to identify an antigen binding event.
Are the sequences of IgG's from various species and for various
antigens known ? How can I know whether there are luminescent
amino acid residues in the binding pocket of a particular
antibody ? Can these properties be engineered ?
ebstokes at crd.ge.com