In article <1992Feb5.202309.22818 at coe.montana.edu> umbjs at cs.montana.edu (Jean Starkey) writes:
/>
/> I would like to know the programs that will
/>allow me align primary sequences of polypeptides of
/>about 400 amino acids long, to see if there any
/>significant homology. I have used FASTA and BESTFIT
/>and other programs on the GCG package available on
/>the front end of the Pittsburg super computer.
/>
/> Unfortunately, these programs allow one to
/>align only two sequences at a time. I have seen
/>many papers in which more than half a dozen of
/>sequences aligned. If any one on the net has any
/>information about such programs please let me know
/>at the following E-mail address. I need a program
/>that aligns at least five to six different protein
/>sequences.
/> Thank you very much in advance.
/>
/>
/>Rajani Bommakanti
/>
/>E-mail bommakan at hydrogen.oscs.montana.edu
/>
/> or
/>
/> uchajbk at mtsunix1
/>
/>
/>phone # 406-587-8906 (home-message)
/> 406-994-3926 (lab)
There is an excellent program for doing this called: MACAW (Multiple Alignment
Construction & Analysis Workbench). This is a MS-Windows program that was
written by Gregory D. Schuler of the National Center for Biotechnology
Information. You can get a copy of it from ncbi.nlm.nih.gov by anonymous
FTP. Look for the file macaw***.zip where *** refers to the current version
number.
--
Donald A. Lehn, Ph.D. Phone: (301) 496-2885
Bldg.37 Rm 3D20 FAX: (301) 496-8419
National Cancer Institute / NIH Email: donnel at helix.nih.gov
Bethesda MD 20892
