There has been quite a lot of work done on this area. You could try Von Heijne,
G. (1986) "A new method for predicting signal sequence sites" Nucl. Acids. Res.
14:4683-4690 for a start.
Craig Marshall bioc07 at otago.ac.nz
Department of Biochemistry Fax +64 3 479 7866
University of Otago Phone +64 3 479 7871
PO Box 56
Dunedin
New Zealand
