Compact course on Computational Biochemistry
Proff. Gaston H. Gonnet, Steven A. Benner
March 19./20. 1992 at ETH Zurich, Switzerland
This course will give the mathematical and algorithmic principles used in
computational biochemistry and illustrate them with hands-on experience
using the Darwin system over various databases.
Topics:
* Sequence alignment
- Independent mutations model, mutation matrices, PAM distance and
Dayhoff matrices
- Dynamic programming algorithms and simplified variations
- Estimating PAM distances or amount of evolution
- Homology and 3-D structure
- Insertions/deletions modelling
- Aligning DNA sequences
- All-against-all matching
* Pattern recognition ins sequences
- Maximum repetitions
- K-gram repetition
- Prosite-style patterns and pattern searching
- One-against-all matching
* Phylogenetic trees
- Reconstruction of the topology of phylogenetic trees
- Evolutionary phylogenetic trees
- Probabilistic ancestral sequences
- Multiple alignments
* Overview of available databases and tools
- Databases
- Introduction to the Darwin system
Course language: English
Application and Information:
Departement Informatik, Fortbildungskurse
ETH-Zentrum, CH-8092 Zurich
Switzerland
Phone +41 1 254 72 06, Fax +41 1 262 39 73
Cost: SFr. 800.- per participant.
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Domain: curtiss at umiacs.umd.edu Phillip Curtiss
UUCP: uunet!mimsy!curtiss UMIACS - Univ. of Maryland
Phone: +1-301-405-6710 College Park, Md 20742
