ghj at mrc-lmb.cam.ac.uk (Jacobs "G.") writes:
>Just to add to the confusion, at least some of the DNA proteins with
>more than one DNA binding domain can select between them via alt.
>splicing. This could appear as activating at two different sites in
>some assays I guess (I'm not an experimentalist, but it does seem an
>obvious point...).
>I could give you some examples later (I'm not at my lab. at the
>moment).
The Kafatos lab published a pair of papers on this in a recent Science
(about 1 month ago?)
>A point for myself is to distinguish between whether the protein binds
>the two promoters *AT THE SAME TIME* or whether it is able to bind
>the two promoters, but independently. Two very different things!
>Grant Jacobs
>MRC Laboratory of Molecular Biology
>Hillls Road
>Cambridge CB3 9EU
>ENGLAND.
Keith Robison
Harvard University
Department of Cellular & Developmental Biology
Department of Genetics / HHMI
robison at biosun.harvard.edu
