IUBio

Prion Digest V1 #3

Chris Swanson, Moderator prion at STOLAF.EDU
Sat Mar 30 05:00:56 EST 1991


Prion Digest                Sat, 30 Mar 91       Volume 1 : Issue   3 

Today's Topics:
                             Fwd'd reply

The "Prion Digest" is a Usenet distributed e-mail list, compiled from
postings to it, and distributed weekly (current plan is for early Sat.
A.M.)

While the main goal of the digest is to provide a resource for
researchers working with prions and interested bystanders, all are
welcome.  All articles posted will be included in the next digest.  If
a poster feels that his posting is of an urgent nature, it may be
distributed sooner than the regular digest.  If you want to post an
"urgent" message send it to the prion-request address, not the prion
one.

All requests regarding administrivia (subscriptions, cancellations,
comments, etc.) should be mailed to the moderator 
<prion-request at acc.stolaf.edu>.  All postings to the digest should be
directed to <prion at acc.stolaf.edu>.

There are archives of all back issues available via anonymous ftp from
beowulf at acc.stolaf.edu (130.71.192.20) in the pub/prion directory.  If
you do not have ftp access, please write <prion-archive at acc.stolaf.edu>
and back issues will be mailed to you.

	-- Chris Swanson (Prion Digest Moderator)  <swansonc at acc.stolaf.edu>

----------------------------------------------------------------------

Date: Wed, 27 Mar 1991 18:09:19 WET
From: swansonc at stolaf.edu (Chris Swanson)
Subject: Fwd'd reply
To: prion

Enclosed below is a forwarded response to the NA query in the last issue.
 
         -Chris
 
> > To: Prion-request at stolaf.edu
> > Subject: Re:  Prion Digest V1 #2
> > Resent-To: prion
> > 
> > we've been looking for nucleic acid in prions for 2 or 3 years
> > basicly since there doesn't seem to be any compelling evidence
> > that prions are unusual.  When we look we find that there is
> > enough nucleic acid for there to be a copy or two of a decent
> > sized nucleic acid for each infectious unit.  Dr. Prusiner's
> > lab has published similar quantitations recently in the Journal
> > of General Virology.  The trouble is as of yet there is no
> > published evidence for any specific discrete nucleic acid that
> > consistently occurs in "prions", and that will take a while to
> > find and prove.  we have our own ideas like many other labs
> > why this is true.  we have some unproven candidate nucleic 
> > acids that we are checking out, but this takes quite a bit of
> > time.  
> > 
> > The other camp is gathering momentum for the absence of an
> > essential nucleic acid and this is best discussed in News and
> > Views type articles that have just come out in Nature and Science.
> > 
> > Steve Wietgrefe   U. of Minnesota
> > 
> > ------- End of Unsent Draft
> > 
> 

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End of Prion Digest
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