"Henry Harpending" <harpend at xmission.com> wrote in message
news:bukd90$h77$1 at mercury.hgmp.mrc.ac.uk...
> Can someone point me to any recent review or discussion
> of inference from the frequency spectrum of synonymous versus non-
> synonymous segregating sites in a collection of DNA sequences from the
>> I am looking at a big collection of BRCA1 sequences, coding stuff only,
> there 146 synonymous segregating sites and 839 non-synonymous, which seems
> pretty strange to me. Too many non-syn mutations?
what do you mean by "segregating" here. Do you have a multiple alignment of
BRCA1 DNA sequences?
>> Thanks, Henry Harpending