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synonymous vs. nonsynonymous segregating sites

Des Higgins fatherdes at eircom.net
Sat Jan 24 05:36:48 EST 2004


"Henry Harpending" <harpend at xmission.com> wrote in message
news:bukd90$h77$1 at mercury.hgmp.mrc.ac.uk...
> Can someone point me to any recent review or discussion
> of inference from the frequency spectrum of synonymous versus non-
> synonymous segregating sites in a collection of DNA sequences from the
same
> species?
>
> I am looking at a big collection of BRCA1 sequences, coding stuff only,
and
> there 146 synonymous segregating sites and 839 non-synonymous, which seems
> pretty strange to me.  Too many non-syn mutations?


Hi Henry;

what do you mean by "segregating" here.  Do you have a multiple alignment of
BRCA1 DNA sequences?

Des Higgins


>
> Thanks, Henry Harpending
> ---

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