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sequence divergence puzzle

Mark Dowton Mark_Dowton at uow.edu.au
Mon Feb 1 11:36:05 EST 1999


Sam,

Could this be an indication of compositional bias?  It sounds like you
have more similarity at synonymous sites than non-synonymous sites; what
are the %G, C, T, and A values for the two sequences?

Cheers, Mark
In article <78vf24$qmh at net.bio.net>, Sam King <mjkg at dna.bio.warwick.ac.uk>
wrote:

> I am not an evolutionary biologist but I am in the middle of writing
> my thesis and have a problem understanding this information. I have
> two sialidase genes from streptococcus pneumoniae which are more
> conserved at the nucleotide level (60%) than the amino acid level
> (53%). I thought this was usually the other way round.
> Ive checked the synonymous/nonsynonymous values using jukes-cantor 
> theyare 1.2+-0.25/0.46+-0.046.
>  Does anyone have any ideas? or other examples like this? 
> Sam king




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