On Wed, 21 Oct 1998 17:53:14, Dr.Ram Samudrala <ram.samudrala at stanford.nojunkemail>
>> Have there been any estimates published on the frequency/distribution
> of nucleotides/amino acids in DNA/protein sequences PRIOR to
> selection, i.e., before selection kicks in? I can get the frequencies
> of amino acids in known protein sequences, but these proteins have
> generally arisen through natural selection.
I'am not sure that this answers your question but in
Lobry, J.R. (1997) Influence of genomic G+C content on average amino-acid
composition of proteins from 59 bacterial species. Gene 205:309-316
you find how to compute theoretical amino-acid frequencies as function of
nucleotidic frequencies in absence of selection. This is not difficult,
you just have to take care that there are no stop codons in coding sequences.
Jean R. Lobry (lobry at biomserv.univ-lyon1.fr)
Laboratoire BGBP-CNRS-UMR-5558, Univ. C. Bernard - LYON I,
43 Bd 11/11/1918, F-69622 VILLEURBANNE CEDEX, FRANCE
phone : (33) 472 43 12 87 fax : (33) 478 89 27 19