Dear molbio.evolution readers,
I am thinking about writing a program to model sequence evolution.
Basically I want to be able to (1) input a known sequence (2)mutate it
using a range of mutation rates and types(ie base pair changes,
insertions, deletions) (3) use my artificially created sequences as a
control group for alignment and phylogenetic analysis. Do you know if
someone has written a program which does this already? Do you know of any
papers or references where people attempted similar projects?
If I do go ahead with this project, I need to establish a reasonable range
of mutation rates / sequence generation (How to set my molecular clock).
If you know of any source for background mutation rates in different
organisms, that would be a great resource. Also any basic reference where
I could find the average size and cause of insertion and deletion
mutations would be helpful.
Thank you for any feedback you might have about this project.
(airlie at mindspring.com)