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What is the SMALLEST DNA BINDING DOMAIN?

jstrassw at OPAL.TUFTS.EDU jstrassw at OPAL.TUFTS.EDU
Sat Jan 11 11:52:26 EST 1997


Hello!
Well, the Bovine Papillomavirus DNA binding domain (minimal) iosonlt 85 AA
although tit forms a dimer.  It has the aadvantage of many characterized
mutations, and an excellent crystal structure (1.2A) and  binds
sequence-specific to a palindropme at 10 -12 M.

I also study it!
John


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John Strasswimmer, MD,PhD Candidate    | Phone (617) 636 8396
Tufts - New England Medical Center     | Fax   (617) 636 6190
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     *** Co-Author of "HyperBug" Microbiology Teaching Software ***
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On Fri, 10 Jan 1997, MThompson wrote:

> I am searching for a small independently folding (or in presence of a
> metal ion), DNA binding domain. Would like it to be sequence specific, but
> would greatly appreciate all suggestions. Be as detailed as possible or
> please cite a reference, or name that I can locate it in the literature.
> Thanks very much.
> 
> 




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