I am (still) searching a a reliable method for calculating divergence time
between members of a multigene family, with the members having different
evolutionary rates? Between orthologous sequences synonymous substitution
rates are fairly constant (3*10-9 per site per year), while nonsynonymous
substitution rates range from 0.021-0.76*10-9. Between paralogous sequences
the number of synonymous substitutions per site can not be accurately
Who has any suggestions?