Bacteriophage T4 DNA polymerase mutations that affect spontaneous mutation
rates have been extensively studied by Linda Reha-Krantz and her colaborators.
Mutations deficient in 3'-5' exonuclease activity dramatically increase
spontaneous mutation and the results are in PNAS 88:2417 (1991). I heard her
recent study on antimutator mutants of T4 DNA polymerase. People who are
interested in this issue may have to contact Linda for detail.
Department of Microbiology
University of Saskatchewan
Saskatoon, SK, Canada S7N 0W0