johnest at ulrik.uio.no (John E. Stacy) writes:
>I want to know if anyone out there has experience with (vertebrate) mtDNA -
>In particular, how much intraspecific variation is there in the "D-loop"?
>Regarding intraspecific variation, is it all at the level of single base
>changes, or are there length variations (i.e. detectable as PCR product
>All comments and references greatly appreciated.
D-loop polymorphisms were used extensively by the late A.C. Wilson
and co-workers in their studies of human evolution, as well as many
other studies. Some references are:
PNAS 88:1597. 1991
Nature 350: 467. 1991.
Mol.Biol.Evol. 8:475. 1991.
You might also try looking in the subject indices of J.Mol.Evol and
Mol.Bio.& Evol year end issues under "D-loop" or "mitochond-".
Department of Cellular & Developmental Biology
Department of Genetics / HHMI
robison at biosun.harvard.edu