Could anyone point me to some references that provide statistical
methods for evaluating family based linkage to mitochrondrial polymorphisms.
For some of the complex traits/diseases there are published association studies
of unrelated cases and controls. For other diseases (e.g. LHON)
it appears sufficient to demonstrate that there is a functional polymorphsim
present in affected members but not in unaffected members. Any thoughts
about screening families for mtDNA variants and statistically evaluating
linkage?
thanks,
Anita
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Anita DeStefano, Ph.D.
Boston University Medical Center
Dept of Neurology and Epidemiology & Biostatistics TEL: 617 638-4057
80 E Concord St. FAX: 617 638-4275
Boston, MA 02118-2394 email: destefano at med-genepi.bu.edu
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