Dear netters,
I am studying the occurrence of a gene allele polymorphism (A- and
B-allele) in relation to hypertrophy. I have analysed the allele
frequencies in relation to the hypertrophy data in three models.
- a recessive model for the B-allele: AA+AB vs BB
- a dominant model for the B-allele: AA vs AB+BB
both models with a Student's t test, and
- a co-dominant model: AA vs AB vs BB
with ANOVA analysis.
Now a reviewer of a journal in wich I want to publish my data states
that my co-dominant model actually is an assumption of additive
inheritance.
Can somebody tell me what is meant by additive inheritance and in what
way does it differ from a co-dominant phenotype of alleles. As far as I
understand co-dominant means that the phenotype of the heterozygote
differs from both the homozygotes.
A question concerning the statistics is whether or not one needs to
perform a Bonferroni correction, in this case of a factor three as three
different analysis have been performed on the 'same' data.
I am looking forward for your responses as I have never been in
population genetics before let be statistics,
With best regards,
Arthur Osterop, PhD
Erasmus University Rotterdam
osterop at tch.fgg.eur.nl
