Hi,
Could someone help with this question:
I have a biallelic polymorphism (G & A) linked to a dinucleotide repeat
with a number of variants (approx 88 to 120). Both are quite frequent in the
population or rather all the alleles are above 20%. Question.. how can I
demonstrate linkage disequilibrium between the G allele and repeat allele
106? Looking at a random sample of 100 individuals. I thought that to
address the question of phase I could analyse G/G and A/A homozygotes for
the occurrence of the 106 allele. When I did this I found a significant
disequilibrium between 106 and G with a p value of < .0001. This test of
homozygotes makes sense to me but is it a legitimate approach?
Thanks
Phil
