WELLCOME TRUST SUMMER SCHOOLS
SEVENTEENTH ADVANCED COURSE
HUMAN GENOME ANALYSIS:
GENETIC ANALYSIS OF MULTIFACTORIAL DISEASES
21st - 26th July 1996
The Wellcome Trust Centre for Human Genetics, University of Oxford
Windmill Road, Headington, Oxford, OX3 7BN
An intensive computer-based course aimed at scientists actively involved
in genetic analysis of multifactorial traits.
Programme
For each of the following areas, we will discuss issues of power to detect
linkage, optimal study design, use of software, and proper statistical
analyses:
1. Qualitative traits: sib-pair methods
2. Qualtitative traits: affected-relative methods
3. Quantitative traits: sib-pair methods
4. Quantitative traits: regressive models
5. Linkage disequilibrium: testing for association
Teaching will take the form of lectures by invited speakers, informal
tutorials, hands-on computer sessions and analysis of disease family data
sets. There will also be an opportunity to analyse and discuss
participants' own data sets.
Course Organisers
DANIEL WEEKS, MARK LATHROP.
Confirmed speakers include:
CHRIS AMOS (Houston), DAVID GOLDGAR (Utah), ADRIAN HILL (Oxford), SUN-WEI
GUO (Ann Arbor), PETER HOLMANS (Cardiff), ELLEN WIJSMAN (Seattle).
Participants
Applicants should be scientists at an advanced level of research
(post-doctoral or equivalent). Documentation verifying that the applicant
is actively engaged in a linkage or family-based association study
(animal/human) must be provided with the applica tion. The course is
subsidised by the Wellcome Trust for scientists based in academic
institutions anywhere in the world. This is a residential course, without
exception, and there is a charge of œ350 pounds towards board and lodging.
Applications
There are no formal application forms, but applicants should send a hard
copy of their full CV together with a 300 word outline of their current
and ongoing research plans, indicating the relevance of the course, to Dr
Pelin Faik, Course Co-ordinator, Div ision of Biochemistry & Molecular
Biology, UMDS, Guy's Campus, London Bridge SE1 9RT. Notification of places
will be in May. Further information on http://www.umds.ac.uk/wlmg.
Tel: 0171 403 6998
Fax: 0171 407 5281
Email: wss at umds.ac.uk
Closing date for applications is 29th March 1996
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COURSE SUMMARY
For each of the following areas, we will discuss issues of power to detect
linkage, optimal study design, use of software, and proper statistical
analyses:
1 Qualitative traits: sib-pair methods
Comparison of identity-by-descent, identity-by-state and maximum
likelihood methods of affected sib-pair analysis.
2 Qualitative traits: affected-relative methods
General non-parametric tests aimed at detecting linkage by testing for
increased marker similarity between the affected members of a pedigree.
3 Quantitative traits: sib-pair methods
Comparison of different methods, including the Haseman-Elston
least-squares regression procedure, variance components methods, and
multilocus approaches.
4 Quantitative traits: regressive models
How to model familial correlations in the presence of major gene effects
and other sources of familial correlations.
5 Linkage disequilibrium: testing for association
Use of tests for linkage disequilibrium between markers and disease,
including the haplotype relative risk (HHR) and
transmission/disequilibirium (TDT) tests.
