IUBio

haplotyping

Phil Green phg at U.WASHINGTON.EDU
Sat Aug 10 10:31:13 EST 1996



On 10 Aug 1996, Daniel E. Weeks wrote:

> On 6 Aug 1996 jea at ukrv.de wrote:
> > I need a computer program to do haplotyping. CAn everyone help me.
> >
> It depends on what you mean by 'haplotyping'.  I believe Dr. Stivers'
> response referred to computing haplotype frequencies.  If instead you
> are interested in inferring most likely haplotypes for codominant marker
> data on pedigrees, see:
>
>   Sobel  E, Lange K, O'Connell JR, Weeks DE (1996) Haplotyping
>      algorithms. In: Speed TP, Waterman MS (eds) Genetic  mapping
>      and DNA sequencing. Springer-Verlag, New York.
>
>   Weeks  DE,  Sobel  E, O'Connell JR, Lange K (1995)  Computer
>      programs for multilocus haplotyping of general pedigrees. Am
>      J Hum Genet 56:1506-1507
>
> (as well as the recent article by Sobel & Lange in the June 1996
> American Journal of Human Genetics).
>
> Our programs for haplotyping are available by anonymous ftp to
> watson.hgen.pitt.edu (or on the EBI mirror site at ftp.ebi.ac.uk).
>
> Also, the GeneHunter program of Kruglyak and colleagues performs rapid
> haplotyping on small pedigrees.

The program CRIMAP (first distributed in 1988) also does haplotyping of
codominant markers, on arbitrary pedigrees.

Phil Green

>
> Hope that helps.
>
> Sincerely,
>   -- Dan Weeks --
>
>
>
>




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