Alex Ext. 4983 - Medicine <NECHIPORUK at CSMC.EDU> wrote:
>chosen proband using data from one marker. My question is: is there a way
>to put data from a couple closely linked markers simulteniuiously and then
>get an estimation of genetic risk?
hi alex,
yeah, it's very simple - assume that your disease is locus 1 - then in
the final screen of LCP enter your "Locus order []:" data as
'2 1 3' - where your marker loci are 2nd and 3rd in the pedin.dat file.
LINKAGE should then give you a flanking-marker risk calculation.
we do this on a semi-regular basis, and it works fine. you could
also do a run with locus order "2 3 1" where your two markers are
on one side of the disease gene, but i dont think that will give
you much added information...
Iain Fenton, Cardiff, UK.
