>>I am looking for a program that would allow me to determine what is the e
>>best fit mode of inheritance (X linked, dominant.recessive...etc) of a
>>particular trait among pedigree that I have collected. If anyone knows of
>>such program I would be pleased to hear about it
>>There's one called POINTER which Morton and MacLean wrote. It's a bit long in
>the tooth now, but I don't know of a better one. If you can't find anything
>better and need help getting hold of it then contact me. I don't have any
>documentation though.
>
PAP and S.A.G.E. are both more current; probably also more reliable.
We tried POINTER many years ago & found that it gave different answers
on the identical data set when run on different computers. Both PAP
and S.A.G.E. are currently maintained; POINTER is not. PAP is
distributed by S. Hasstedt in Utah; S.A.G.E. is distributed by R. Elston
in Louisiana (soon to move to Case-Western).
Another alternative, especially for traits which do not have a complex
mode of inheritance is MENDEL/FISHER. MENDEL and FISHER are distributed
by K. Lange, who is now at U. of Michigan.
Ellen Wijsman
Research Associate Professor
Div of Medical Genetics, RG-25
and Dept of Biostatistics
University of Washington
Seattle, WA 98195
wijsman at u.washington.edu
